C-radiolabeled aptamer for imaging of tumors and metastases using positron emission tomography- computed tomography


Identification of primary tumors and metastasis sites is an essential step in cancer diagnostics and the following treatment. Positron emission tomography-computed tomography (PET/CT) is one of the most reliable methods for scanning the whole organism for malignancies. In this work, we synthesized an 11C-labeled oligonucleotide primer and hybridized it to an anti-cancer DNA aptamer. 

The C-aptamer was applied for in vivo imaging of Ehrlich ascites carcinoma and its metastases in mice using PET/CT. The imaging experiments with the C-aptamer determined very small primary and secondary tumors of 3 mm2 and less. We also compared C imaging with the standard radiotracer, 2-deoxy-2-[fluorine-18]fluoro-D-glucose (18F-FDG), and found better selectivity of the C-aptamer to metastatic lesions in the metabolically active organs than F-FDG. 

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