Selection of aptamers for whole cells, bacteria, fungi, tissues or proteins in vitro or in vivo for pathologic or healthy organs/tissues in the organism of experimental mice
Aptamer Selection, Characterization, 3D Structure Simulation And Target Identification
SENSITIVITY AND SPECIFICITY OF THE SELECTED APTAMERS IS AT LEAST 85%
WE USE INDIVIDUAL SELECTION TACTICS FOR EACH TARGET
100% EFFICIENCY OF the SELECTED APTAMERS FOR DIAGNOSTICS AND THERAPY
Mathematical analysis of sequenced aptamer pools after the Next Generation Sequencing which allows us to choose leading sequences and to estimate the enrichment of aptamers during selection
Estimation of affinity, specificity and dissociation constant of synthetic aptamers using flow cytometry and laser scanning microscopy
Definition of the of aptamer tertiary structure in buffer using Small Angle X-ray Scattering with the following molecular design
Protein target identification using Aptamer-facilitated Biomarker Discovery technique and mass-spectrometry analysis with the following target verification by concurrent antibody replacement and co-staining
Our team is ready to do all the best to solve YOUR tasks
85% AND MORE
FULL Work CYCLE BY OUR TEAM
ON REAL SAMPLES
Aptamers for the diagnosis of lung cancer
Aptamers were selected from a DNA library of oligonucleotides using the Cell SELEX method...
Aptamers for intraoperative staining of brain glioblastoma
Aptamers were selected from a DNA library of oligonucleotides using the Cell SELEX method to postoperative glioblastoma tissues...
Aptamers for the detection of bacteria Salmonella typhimurium and Salmonella eneritidis
Highly specific DNA aptamers to live Salmonella typhimurium and Salmonella eneritidis were selected via the SELEX technique...