Aptamer Selection
Selection of aptamers for whole cells, bacteria, fungi, tissues or proteins in vitro or in vivo for pathologic or healthy organs/tissues in the organism of experimental mice
APTAMER services
FULL work CYCLE WITH APTAMERS: FROM SELECTION TO
THREE-DIMENSIONAL CONFORMATION
Mathematical Analysis of Sequences
Mathematical analysis of sequenced aptamer pools after the Next Generation Sequencing which allows us to choose leading sequences and to estimate the enrichment of aptamers during selection
Aptamer Characterization
Estimation of affinity, specificity and dissociation constant of synthetic aptamers using flow cytometry and laser scanning microscopy
Aptamer DESIGN AND 3D Structure
Definition of the of aptamer tertiary structure in buffer using Small Angle X-ray Scattering with the following molecular design
Target Identification and Verification
Protein target identification using Aptamer-facilitated Biomarker Discovery technique and mass-spectrometry analysis with the following target verification by concurrent antibody replacement and co-staining.