APTAMER services

FULL work CYCLE WITH APTAMERS: FROM SELECTION TO 
THREE-DIMENSIONAL CONFORMATION

Aptamer Selection

Aptamer Selection

Selection of aptamers for whole cells, bacteria, fungi, tissues or proteins in vitro or in vivo for pathologic or healthy organs/tissues in the organism of experimental mice 

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MATHEMATICAL ANALYSIS OF APTAMERS

Mathematical Analysis of Sequences

Mathematical analysis of sequenced aptamer pools after the Next Generation Sequencing which allows us to choose leading sequences and to estimate the enrichment of aptamers during selection

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APTAMER CHARACTERIZATION

Aptamer Characterization

Estimation of affinity, specificity and dissociation constant of synthetic aptamers using flow cytometry and laser scanning microscopy

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3D STRUCTURE AND MOLECULAR DESIGN

Aptamer DESIGN AND 3D Structure

Definition of the of aptamer tertiary structure in buffer using Small Angle X-ray Scattering with the following molecular design

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IDENTIFICATION OF PROTEIN TARGETS

Target Identification and Verification

Protein target identification using Aptamer-facilitated Biomarker Discovery technique and mass-spectrometry analysis with the following target verification by concurrent antibody replacement and co-staining.

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